If you read lots of feeds in Reader then the number of items waiting to be read can be intimidating. You know you have to process all news items, because new ones are coming continuously and you'll be overwhelmed if you don't read the ones you have in Reader already.
This is very stressful. I know, because I've been there.
The solution: employ a more casual approach to the reading of news. Collect similar feeds (e.g. economics, entertainment, etc.) into a common folder and use the folder to read all the relevant feeds mixed together. The secret is you don't have to read all items. Just skim the river of news and stop at an item which captures your attention. Don't worry about the others. If something is really important it will come around again.
This way you can use Reader in a more relaxed way. No more stress, more efficiency. :)